Manifestations of Collagen Diseases

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چکیده

T HE first descriptions of disease entities, which today are included in the category of "collagen diseases," were made more than a century ago. Through the decades many more entities were described clinically, but until recent years no fundamental common denominator was suspected. Significant contributions which went beyond mere clinical and morphological recognition were made after 1930. The studies of Rich and Gregory,1 confirming older observations that vascular changes resembling polyangiitis can be produced experimentally by foreign proteins and allergens, have become common knowledge. Much investigative work has been carried out to apply this concept to all the other entities in this category. These attempts have met with success or failure depending on the type of disease investigated. Even more fruitful was the concept proposed by Klemperer and co-workersx2 that these diseases primarily involve the connective tissue structures. The latter then would react like an organ system. Due to the diffuseness of mesenchymal tissue the manifestations would be protean. This important concept provided a great stimulus to research concerning the physiology, histochemistry and physical properties of connective tissues. An intensive search for abnormalities in these respects has been carried out by numerous investigators with the result that many

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تاریخ انتشار 2005